On the sample size of clinical trials
نویسندگان
چکیده
منابع مشابه
Sample size for clinical trials
An outcome variable is one which we hope to change, predict or estimate in a trial. Examples: • Systolic blood pressure in a hypertension trial • Caesarean section rate in an obstetric trial • Survival time in a cancer trial How many outcome variables should I have? If we have many outcome variables: • all possibilities would be covered, • we would be less likely to miss something, • the risk o...
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Adaptive clinical trials are becoming very popular because of their flexibility in allowing mid-stream changes of sample size, endpoints, populations, etc. At the same time, they have been regarded with mistrust because they can produce bizarre results in very extreme settings. Understanding the advantages and disadvantages of these rapidly developing methods is a must. This paper reviews flexi...
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A decision theoretic framework for sample size determination for a clinical trial is presented in which the nal decision whether to use the new treatment is taken by potential users and their medical advisers on the basis of the strength of the evidence provided by the trial. This is more realistic than the usual decision theoretic assumption that both the sample size and terminal decisions are...
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ژورنال
عنوان ژورنال: Journal of Orthodontics
سال: 2018
ISSN: 1465-3125,1465-3133
DOI: 10.1080/14653125.2018.1501929